Telomerase Activation Research Compound

TAC, also known as TERT activator compound, is a small molecule investigated for its ability to increase telomerase reverse transcriptase (TERT) gene transcription through the MEK/ERK/AP-1 signaling pathway.

Research Background

Shim and colleagues reported in Cell (2024) that TAC increased TERT expression in primary human cells and naturally aged mice. The study examined telomere synthesis, cellular senescence, inflammatory signaling, and DNMT3B-mediated regulation of p16 expression. These findings are from preclinical research and do not establish efficacy or safety in humans.

Product Details

Amount: 1 gram
Format: Powder
Purity: 99.9% by quantitative NMR (qNMR)
CAS: 666699-46-3
Molecular formula: C14H12ClF2NO2S
Molecular weight: 331.77 g/mol
Chemical name: N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide
Category: Telomerase

Research Publication

Shim HS et al. TERT activation targets DNA methylation and multiple aging hallmarks. Cell. 2024;187(15):4030–4042.e13.

For laboratory research use only. Not for human consumption or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.