MVD1 / SANA

Creatine-Dependent Thermogenesis Research Compound

MVD1, also known as SANA, is an investigational small molecule derived from the salicylate chemical scaffold. SANA stands for salicylic acid nitroalkene and is chemically identified as 5-(2-nitroethenyl)salicylic acid.

Unlike metabolic research agents that primarily influence appetite-related hormone receptors, MVD1 is being studied for its ability to influence cellular energy expenditure within adipose tissue. Published research suggests that it stimulates mitochondrial respiration and creatine-dependent thermogenesis—a process through which the creatine and phosphocreatine cycle contributes to cellular heat production and energy use.

Areas of Research Interest

MVD1 / SANA is being investigated in research involving:

• Creatine-dependent thermogenesis

• Mitochondrial respiration in adipose tissue

• Cellular energy expenditure

• Creatine kinase proteins CKMT1 and CKMT2

• UCP1-independent thermogenic pathways

• AMPK-independent metabolic signaling

• Adipose-tissue glucose and lipid metabolism

• Experimental models of insulin resistance

• Experimental models of hepatic steatosis

• Nitroalkene and salicylate structure–activity relationships

Preclinical studies found that SANA increased energy expenditure and reduced diet-induced weight gain, insulin resistance, and liver-fat accumulation in animal models without producing a corresponding reduction in food intake.

MVD1 has also undergone a randomized, double-blind, placebo-controlled Phase 1A/B study evaluating its safety, tolerability, pharmacokinetics, and exploratory metabolic effects. These early findings remain investigational and do not establish MVD1 as an approved treatment.

Chemical Information

Research name: MVD1
Alternative name: SANA
Full name: Salicylic acid nitroalkene
Chemical name: 2-Hydroxy-5-(2-nitroethenyl)benzoic acid
CAS number: 42571-07-3
Molecular formula: C₉H₇NO₅
Molecular weight: 209.16 g/mol
Form: Research-grade powder
Purity: Refer to the product-specific certificate of analysis

Research References

Cal K. et al. “A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis.” Nature Metabolism, 2023.

Cal K. et al. “A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss.” Nature Metabolism, 2025. DOI: 10.1038/s42255-025-01311-z.

Research Use Only

This product is supplied exclusively for qualified laboratory, analytical, and preclinical research. It is not a dietary supplement, food, cosmetic, medication, or finished pharmaceutical product.

Not for human or veterinary use. Not for ingestion, administration, diagnostic use, or therapeutic applications. This material should be handled only by trained professionals using appropriate laboratory safety procedures.