{"title":"Metabolic","description":"","products":[{"product_id":"slu-pp-332-1-gram","title":"SLU-PP-332","description":"\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003eSLU-PP-332 is a synthetic small-molecule ERR agonist offered by Molecule Frontier for advanced laboratory research. As a pan-agonist of the estrogen-related receptor family — ERRα, ERRβ, and ERRγ — SLU-PP-332 is used in preclinical studies exploring mitochondrial function, oxidative metabolism, cellular respiration, and exercise-mimetic signaling pathways.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"isSelectedEnd\"\u003e\u003cspan\u003ePublished research has evaluated SLU-PP-332 in skeletal muscle and metabolic models, where ERR activation was associated with changes in mitochondrial activity, fatty-acid oxidation, oxidative muscle-fiber markers, and endurance-related gene programs. This makes SLU-PP-332 a valuable research tool for scientists studying nuclear receptor biology, mitochondrial bioenergetics, metabolic flexibility, and the transcriptional programs that overlap with aerobic exercise adaptation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFor research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.\u003c\/span\u003e\u003c\/p\u003e","brand":"Molecule Frontier","offers":[{"title":"3g","offer_id":45666652618805,"sku":null,"price":89.0,"currency_code":"USD","in_stock":true},{"title":"1 gram","offer_id":45666668871733,"sku":null,"price":39.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0707\/9929\/4517\/files\/slupp-332-molecule-white-black.png?v=1782441745"},{"product_id":"mvd1-sana","title":"MVD1 \/ SANA","description":"\u003ch2\u003eMVD1 \/ SANA\u003c\/h2\u003e\n\u003ch3\u003eCreatine-Dependent Thermogenesis Research Compound\u003c\/h3\u003e\n\u003cp\u003eMVD1, also known as \u003cstrong\u003eSANA\u003c\/strong\u003e, is an investigational small molecule derived from the salicylate chemical scaffold. SANA stands for \u003cstrong\u003esalicylic acid nitroalkene\u003c\/strong\u003e and is chemically identified as \u003cstrong\u003e5-(2-nitroethenyl)salicylic acid\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eUnlike metabolic research agents that primarily influence appetite-related hormone receptors, MVD1 is being studied for its ability to influence \u003cstrong\u003ecellular energy expenditure within adipose tissue\u003c\/strong\u003e. Published research suggests that it stimulates mitochondrial respiration and creatine-dependent thermogenesis—a process through which the creatine and phosphocreatine cycle contributes to cellular heat production and energy use.\u003c\/p\u003e\n\u003ch3\u003eAreas of Research Interest\u003c\/h3\u003e\n\u003cp\u003eMVD1 \/ SANA is being investigated in research involving:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003eCreatine-dependent thermogenesis\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eMitochondrial respiration in adipose tissue\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eCellular energy expenditure\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eCreatine kinase proteins CKMT1 and CKMT2\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eUCP1-independent thermogenic pathways\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eAMPK-independent metabolic signaling\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eAdipose-tissue glucose and lipid metabolism\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eExperimental models of insulin resistance\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eExperimental models of hepatic steatosis\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003eNitroalkene and salicylate structure–activity relationships\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003ePreclinical studies found that SANA increased energy expenditure and reduced diet-induced weight gain, insulin resistance, and liver-fat accumulation in animal models without producing a corresponding reduction in food intake.\u003c\/p\u003e\n\u003cp\u003eMVD1 has also undergone a randomized, double-blind, placebo-controlled Phase 1A\/B study evaluating its safety, tolerability, pharmacokinetics, and exploratory metabolic effects. These early findings remain investigational and do not establish MVD1 as an approved treatment.\u003c\/p\u003e\n\u003ch3\u003eChemical Information\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eResearch name:\u003c\/strong\u003e MVD1\u003cbr\u003e\u003cstrong\u003eAlternative name:\u003c\/strong\u003e SANA\u003cbr\u003e\u003cstrong\u003eFull name:\u003c\/strong\u003e Salicylic acid nitroalkene\u003cbr\u003e\u003cstrong\u003eChemical name:\u003c\/strong\u003e 2-Hydroxy-5-(2-nitroethenyl)benzoic acid\u003cbr\u003e\u003cstrong\u003eCAS number:\u003c\/strong\u003e 42571-07-3\u003cbr\u003e\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C₉H₇NO₅\u003cbr\u003e\u003cstrong\u003eMolecular weight:\u003c\/strong\u003e 209.16 g\/mol\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Research-grade powder\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e Refer to the product-specific certificate of analysis\u003c\/p\u003e\n\u003ch3\u003eResearch References\u003c\/h3\u003e\n\u003cp\u003eCal K. et al. “A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis.” \u003cem\u003eNature Metabolism\u003c\/em\u003e, 2023.\u003c\/p\u003e\n\u003cp\u003eCal K. et al. “A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss.” \u003cem\u003eNature Metabolism\u003c\/em\u003e, 2025. DOI: 10.1038\/s42255-025-01311-z.\u003c\/p\u003e\n\u003ch3\u003eResearch Use Only\u003c\/h3\u003e\n\u003cp\u003eThis product is supplied exclusively for qualified laboratory, analytical, and preclinical research. It is not a dietary supplement, food, cosmetic, medication, or finished pharmaceutical product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNot for human or veterinary use. Not for ingestion, administration, diagnostic use, or therapeutic applications.\u003c\/strong\u003e This material should be handled only by trained professionals using appropriate laboratory safety procedures.\u003c\/p\u003e","brand":"Molecule Frontier","offers":[{"title":"60 capsules 200mg","offer_id":45769431220277,"sku":null,"price":129.0,"currency_code":"USD","in_stock":true},{"title":"120 capsules 200mg","offer_id":45769431253045,"sku":null,"price":229.0,"currency_code":"USD","in_stock":true},{"title":"12 grams powder","offer_id":45995263492149,"sku":null,"price":119.0,"currency_code":"USD","in_stock":true},{"title":"24 grams powder","offer_id":45995270930485,"sku":null,"price":215.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0707\/9929\/4517\/files\/MVD1.png?v=1784060338"},{"product_id":"slu-pp-915-500mg","title":"SLU-PP-915 500mg","description":"\u003cp\u003e\u003cstrong\u003ePan-ERR Agonist for Metabolic Research\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eSLU-PP-915 is a synthetic small molecule that activates estrogen-related receptors ERRα, ERRβ, and ERRγ. These nuclear receptors regulate pathways involved in mitochondrial function and cellular energy metabolism. SLU-PP-915 is a boronic-acid-containing thiophene carboxamide studied in cell and animal models.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch Background\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThe 2023 discovery study identified SLU-PP-915 as compound 10s and reported activation of ERR-dependent gene expression. A 2024 study investigated ERR-mediated regulation of TFEB and autophagy using SLU-PP-915 in cellular models. A subsequent study, published in the January 2026 issue of \u003cem\u003eThe Journal of Pharmacology and Experimental Therapeutics\u003c\/em\u003e, characterized oral activity and enhanced aerobic exercise capacity in mice.\u003c\/p\u003e\u003cp\u003eThese preclinical findings support use as a research tool for ERR signaling, mitochondrial energetics, and metabolic biology. They do not establish safety, efficacy, or exercise-performance benefits in humans.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eProduct Details\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eAmount: 500 mg\u003cbr\u003eFormat: Powder\u003cbr\u003eCAS: 2285432-92-8\u003cbr\u003eMolecular formula: C17H13BFNO3S\u003cbr\u003eMolecular weight: 341.16 g\/mol\u003cbr\u003eCategory: Metabolic\u003cbr\u003eProduct type: Small Molecule\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch Publications\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eHampton CS et al. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.ejmech.2023.115582\"\u003eDevelopment and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915\u003c\/a\u003e. \u003cem\u003eEuropean Journal of Medicinal Chemistry\u003c\/em\u003e. 2023;258:115582.\u003c\/li\u003e\n\u003cli\u003eLosby M et al. \u003ca href=\"https:\/\/doi.org\/10.1124\/molpharm.124.000889\"\u003eThe Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB\u003c\/a\u003e. \u003cem\u003eMolecular Pharmacology\u003c\/em\u003e. 2024;106(4):164–172.\u003c\/li\u003e\n\u003cli\u003eBillon C et al. \u003ca href=\"https:\/\/doi.org\/10.1016\/j.jpet.2025.103787\"\u003eAn orally active estrogen receptor-related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity\u003c\/a\u003e. \u003cem\u003eThe Journal of Pharmacology and Experimental Therapeutics\u003c\/em\u003e. 2026;393(1):103787.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eFor laboratory research use only. Not for human consumption or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e","brand":"Molecule Frontier","offers":[{"title":"Default Title","offer_id":45954623012917,"sku":null,"price":99.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0707\/9929\/4517\/files\/slu-pp-915-molecule-white-black_f1708eb8-1144-40f5-b573-b6d56489d6bf.png?v=1790045219"}],"url":"https:\/\/moleculefrontier.myshopify.com\/collections\/metabolic-compounds.oembed","provider":"MoleculeFrontier","version":"1.0","type":"link"}